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The Angle Orthodontist Nov 2022
Topics: Humans; Root Resorption; Dental Pulp
PubMed: 36279256
DOI: 10.2319/1945-7103-92.6.815 -
International Journal of Oral Science Jun 2021External cervical resorption (ECR) refers to a pathological state in which resorption tissues penetrate into the dentin at the cervical aspect of the root. Despite being... (Review)
Review
External cervical resorption (ECR) refers to a pathological state in which resorption tissues penetrate into the dentin at the cervical aspect of the root. Despite being latent in its initial phase, ECR could cause severe damage to mineralized dental tissue and even involve the pulp if not given timely diagnosis and treatment. Nevertheless, the etiology of ECR is still poorly understood, which adds to the difficulty in early diagnosis. ECR has received growing attention in recent years due to the increasing number of clinical cases. Several potential predisposing factors have been recognized in cross-sectional studies as well as case reports. In the meantime, studies on histopathology and pathogenesis have shed light on possible mechanisms of ECR. This review aims to summarize the latest findings in the pathogenesis and potential predisposing factors of ECR, so as to provide pragmatic reference for clinical practice.
Topics: Causality; Cone-Beam Computed Tomography; Cross-Sectional Studies; Humans; Root Resorption; Tooth Cervix
PubMed: 34112752
DOI: 10.1038/s41368-021-00121-9 -
The Angle Orthodontist May 2022To evaluate root resorption of lower incisors and canines quantitatively in a group of patients who underwent orthodontic treatment with piezocision and/or a collagen...
OBJECTIVES
To evaluate root resorption of lower incisors and canines quantitatively in a group of patients who underwent orthodontic treatment with piezocision and/or a collagen reinforcement technique with a fully resorbable three-dimensional (3D) collagen xenograft matrix compared with a control group.
MATERIALS AND METHODS
The study sample of this secondary analysis consisted of 32 periodontally healthy patients with angle Class I malocclusion or mild Class II or III malocclusion and moderate irregularity index scores who underwent orthodontic treatment and had before (T0) and after treatment (T1) cone-beam computed tomography scans. Root resorption of lower incisors and canines was assessed quantitatively in the following four groups: the control group received orthodontic treatment without piezocision, experimental group 1 received orthodontic treatment with piezocision, experimental group 2 received orthodontic treatment with piezocision and a 3D collagen matrix, and experimental group 3 received orthodontic treatment with a 3D collagen matrix.
RESULTS
An overall statistically significant decrease in root length from T0 to T1 for all groups was observed (P < .05). However, there was no significant difference among the groups in the amount of root length decrease from T0 to T1.
CONCLUSIONS
Orthodontic treatment combined with piezocision does not increase the risk of root resorption of lower incisors and canines when compared with orthodontic treatment without acceleration techniques. More studies with larger samples should be undertaken to confirm these results.
Topics: Cone-Beam Computed Tomography; Humans; Incisor; Malocclusion, Angle Class I; Root Resorption; Tooth Movement Techniques
PubMed: 35421894
DOI: 10.2319/121520-1009.1 -
Head & Face Medicine Feb 2021Orthodontic root resorptions are frequently investigated in small animals, and micro-computed tomography (μCT) enables volumetric comparison. Despite, due to...
BACKGROUND
Orthodontic root resorptions are frequently investigated in small animals, and micro-computed tomography (μCT) enables volumetric comparison. Despite, due to overlapping histograms from dentine and bone, accurate quantification of root resorption is challenging. The present study aims at (i) validating a novel automated approach for tooth segmentation (ATS), (ii) to indicate that matching of contralateral teeth is eligible to assess orthodontic tooth movement (OTM) and root resorption (RR), (iii) and to apply the novel approach in an animal trial performing orthodontic tooth movement.
METHODS
The oral apparatus of three female mice were scanned with a μCT. The first molars of each jaw and animal were segmented using ATS (test) and manually (control), and contralateral volumes were compared. Agreement in root volumes and time efficiency were assessed for method validation. In another n = 14 animals, the left first upper molar was protracted for 11 days at 0.5 N, whereas the contralateral molar served as control. Following ATS, OTM and RR were estimated.
RESULTS
ATS was significantly more time efficient compared to the manual approach (81% faster, P < 0.01), accurate (volume differences: - 0.01 ± 0.04 mm), and contralateral roots had comparable volumes. Protracted molars had significantly lower root volumes (P = 0.03), whereas the amount of OTM failed to reveal linear association with RR (P > 0.05).
CONCLUSIONS
Within the limits of the study, it was demonstrated that the combination of ATS and registration of contralateral jaws enables measurements of OTS and associated RR in μCT scans.
Topics: Animals; Female; Mice; Molar; Rodentia; Root Resorption; Tooth Movement Techniques; Tooth Root; X-Ray Microtomography
PubMed: 33531044
DOI: 10.1186/s13005-020-00254-y -
BMC Oral Health May 2024Low impacted third molars are usually asymptomatic and are often found by X-ray examination. The removal of asymptomatic low impacted third molars is one of the most...
OBJECTIVE
Low impacted third molars are usually asymptomatic and are often found by X-ray examination. The removal of asymptomatic low impacted third molars is one of the most controversial clinical issues in oral and maxillofacial surgery.
METHODS
In this study, 806 patients with low impacted mandibular third molars (LIMTMs) (full bony impaction) were analyzed to determine the prevalence and risk factors for cystic lesions and adjacent tooth root resorption throughout the patients' entire life cycle.
RESULTS
The results showed that the prevalence of adjacent tooth root resorption and cystic lesions was age-related, exhibiting a trend of first increasing and then decreasing; prevalence peaked at the age of 41 to 45 years old, the prevalence rates were 12.50% and 11.11% respectively. And the lowest prevalence rate was 2.86% and 2.44% in ≥ 61 group and 56- to 60-year age group respectively. Age was an independent risk factor for adjacent tooth root resorption of LIMTMs, whereas age and impaction type (especially inverted impaction) were independent risk factors for cystic lesions.
CONCLUSIONS
The full life cycle management strategy for LIMTMs may need to be individualized. Surgical removal is recommended for LIMTMs in patients younger than 41 to 45 years, especially for inverted, mesioangular, and horizontally impacted LIMTMs. LIMTMs in patients older than 41 to 45 years may be treated conservatively with regular follow-up, but surgical removal of inverted impacted LIMTMs is still recommended to avoid cyst formation.
Topics: Humans; Molar, Third; Tooth, Impacted; Root Resorption; Female; Retrospective Studies; Male; Adult; Middle Aged; Risk Factors; Mandible; Prevalence; Young Adult; Adolescent; Age Factors; Aged
PubMed: 38698359
DOI: 10.1186/s12903-024-04248-z -
Dental Press Journal of Orthodontics 2017Obesity is a wide-spread condition directly or indirectly connected with an increase in the prevalence of a variety of human diseases. It affects over 50% of the western... (Review)
Review
Obesity is a wide-spread condition directly or indirectly connected with an increase in the prevalence of a variety of human diseases. It affects over 50% of the western overall population. In 2017, a thorough analysis of 204 studies on obesity and cancer revealed that the condition increases the risk of the following types of cancer: stomach, colon, rectal, bile duct, pancreatic, esophagus, breast, endometrial, ovarian, kidney and multiple myeloma. The first study aiming at establishing a connection between obesity and the rate of induced orthodontic tooth movement was conducted by Saloom et al; however, it could not effectively nor significantly reveal any direct influence or effect. Despite being identified during the first week, differences could not be explained and treatment time remained unchanged. In spite of lack of studies in the literature on the connection between obesity and the rate of induced tooth movement, in clinical practice, courses or specialized training, we should not have protocols changed nor adopt any measures or expect significant differences between normal-weight and obese individuals. It should be emphasized that unsuccessful cases or cases of root resorption associated with treatment should not be assigned to obesity, since scientific data is insufficient to do so.
Topics: Humans; Obesity; Root Resorption; Tooth Movement Techniques
PubMed: 28746484
DOI: 10.1590/2177-6709.22.3.021-025.oin -
American Journal of Veterinary Research Jul 2012To determine the prevalence and types of tooth resorption in dogs with oral tumors and to compare findings with those for control dogs.
OBJECTIVE
To determine the prevalence and types of tooth resorption in dogs with oral tumors and to compare findings with those for control dogs.
ANIMALS
101 dogs with oral tumors and 128 control dogs that did not have oral tumors and for which dental radiographs were available.
PROCEDURES
Exclusion criteria for dogs included systemic disease, long-term administration of anti-inflammatory drugs, traumatic occlusion, severe semigeneralized or generalized periodontitis, and endodontic disease. For each dog with an oral tumor, histologic sections of biopsy specimens of tumors were examined. Dental radiographic images of dogs were examined, and the presence and type of tooth resorption were determined for each tooth. Statistical analyses were performed to compare data regarding prevalence of tooth resorption.
RESULTS
Teeth at tumor sites in dogs with nonodontogenic tumors were significantly more frequently affected with external inflammatory resorption, compared with teeth at tumor sites in dogs with odontogenic tumors. Teeth at sites distant from tumors in dogs with oral tumors were 3.2 times as likely to have external surface resorption (OR, 3.2; 95% confidence interval, 1.3 to 7.9) and 83.4 times as likely to have external inflammatory resorption (OR, 83.4; 95% confidence interval, 9.7 to 719.6) as teeth in control dogs.
CONCLUSIONS AND CLINICAL RELEVANCE
Resorption of teeth at tumor sites and at sites distant from tumors was common in dogs with oral tumors. Results of the present study will contribute to an understanding of the complex effects of oral tumors on local and distant hard tissues.
Topics: Animals; Dog Diseases; Dogs; Female; Logistic Models; Male; Mouth Neoplasms; Prevalence; Radiography; Retrospective Studies; Tooth Resorption
PubMed: 22738058
DOI: 10.2460/ajvr.73.7.1057 -
Stomatologija 2008External apical root resorption is an iatrogenic consequence of orthodontic treatment, although it may also occur in the absence of orthodontic treatment. Root... (Review)
Review
External apical root resorption is an iatrogenic consequence of orthodontic treatment, although it may also occur in the absence of orthodontic treatment. Root resorption causes root shortening and breaks the integrity of teeth arch and this is very important for successful orthodontic treatment. Orthodontics is probably the only dental specialty that actually uses the inflammatory process as a means of solving functional and aesthetic problems. They should know the risk factors of root resorption and do everything to reduce the occurrence of root resorption. The aim of our review is to find, classify and estimate factors, that can initiate and induce root resorption during orthodontic treatment. The articles from 2002 to 2007 in English related to the topic were identified. Twenty four articles were selected for data collection. The severity and degree of root resorption associated with orthodontic treatment are multifactorial, involving host and environmental factors. The review shows that root resorption is significantly correlated with treatment duration, fixed appliance treatment, tooth structure, individual susceptibility, type of orthodontic tooth movement.
Topics: Disease Susceptibility; Humans; Iatrogenic Disease; Orthodontic Appliances; Orthodontics, Corrective; Risk Factors; Root Resorption; Stress, Mechanical; Time Factors; Tooth; Tooth Movement Techniques
PubMed: 19001842
DOI: No ID Found -
BioMed Research International 2020Dipeptidyl peptidase-4 (DPP-4) inhibitors are used as a treatment for type 2 diabetes mellitus and have also recently been applied to enhance bone quality and density,...
OBJECTIVES
Dipeptidyl peptidase-4 (DPP-4) inhibitors are used as a treatment for type 2 diabetes mellitus and have also recently been applied to enhance bone quality and density, and increase the expression of bone markers. This study aimed to investigate the effect of a DPP-4 inhibitor on orthodontic tooth movement (OTM) and related root resorption in a mouse model.
MATERIALS AND METHODS
Mice were randomly divided into three groups: those undergoing OTM with the addition of a DPP-4 inhibitor (30 g), those undergoing OTM and receiving phosphate-buffered saline (PBS), and those without force loading (control group). OTM was achieved by means of a nickel-titanium closed coil spring that moved the first molar in a mesial direction for 12 days. The distance of OTM was measured using silicone impression. Maxillae were removed for histological analysis or real-time PCR analysis.
RESULTS
The distance of OTM and the number of osteoclasts were significantly decreased after administration of the DPP-4 inhibitor, which also significantly suppressed the number of odontoclasts and root resorption after OTM. Furthermore, the mRNA expression of tumour necrosis factor- (TNF-) and the receptor activator of nuclear factor kappa-B ligand (RANKL) were decreased in DPP-4 inhibitor-treated mice compared with those receiving PBS and control animals.
CONCLUSION
The DPP-4 inhibitor inhibited tooth movement and associated root resorption by blocking the formation of osteoclasts and odontoclasts, respectively. It also appeared to inhibit osteoclastogenesis and odontoclastogenesis by suppressing the expression of TNF- and/or RANKL.
Topics: Animals; Dipeptidyl-Peptidase IV Inhibitors; Male; Maxilla; Mice; Mice, Inbred C57BL; Models, Animal; Molar; Nickel; Osteoclasts; Osteogenesis; RANK Ligand; Root Resorption; Titanium; Tooth Movement Techniques; Tooth Root; Tumor Necrosis Factor-alpha
PubMed: 32923485
DOI: 10.1155/2020/7189084 -
Brazilian Oral Research 2022The understanding of the biological mechanisms involved in root resorption in deciduous teeth is important to the future development of preventive measures and...
The understanding of the biological mechanisms involved in root resorption in deciduous teeth is important to the future development of preventive measures and treatments of this condition. The aim of the present study was to compare the expression and immunostaining of iNOS, MMP-9, OPG and RANKL in the periodontal ligament (PDL) of deciduous teeth with physiologic root resorption (GI), inflammatory pathological root resorption (GII) and permanent teeth (GIII), the negative control. Teeth in GI (n = 10), GII (n = 10) and (GIII) (n = 10) were submitted to immunohistochemical analysis to determine the expression of iNOS, MMP-9, OPG, and RANKL. The immunostaining was analysed by optical density. Statistical analysis included one-way ANOVA, followed by Student-Newman-Keuls post hoc test (p < 0.05). The results showed that iNOS, MMP-9 and RANKL expression in the PDL was higher in GII compared to GI and GIII (p < 0.05). Moreover, RANKL expression was higher in GI compared to GIII (p < 0.001), while OPG immunolabelling was lower in GII compared to GI and GIII (p < 0.001). The PDL of deciduous teeth bearing inflammatory processed exhibited upregulation of resorption-associated factors as well as enzymes related to tissue degradation which, in turn explains the exacerbation and greater susceptibility of those teeth to root resorption process.
Topics: Humans; Periodontal Ligament; Root Resorption; Matrix Metalloproteinase 9; Osteoprotegerin; Tooth, Deciduous; RANK Ligand; Inflammation
PubMed: 36507743
DOI: 10.1590/1807-3107bor-2022.vol36.0056